Epilepsy

Recurrent seizures caused by abnormal brain electrical activity. Most are controlled with medication; surgery is an option when drugs fail.

Pathway
Brain — neurosurgical
Reviewed by
Hussein Imran Mousa, consultant neurosurgeon
Reading time
3 min read
Last reviewed
March 2021

At a glance

What it is

A tendency to have seizures — episodes of involuntary muscle contractions, altered awareness, or unusual sensations caused by abnormal electrical discharge in the brain.

Typical signs

Sudden loss of consciousness with stiffening and jerking (tonic-clonic); or absences (brief lapses where the person stares blankly); or focal awareness with hand automatisms.

How we treat it

First-line is anti-seizure medication (AEDs). When drugs fail or cause intolerable side effects, surgery to remove or disconnect the seizure-generating zone offers seizure freedom.

What epilepsy is

Epilepsy is a disorder of recurrent, unprovoked seizures. A single seizure does not make epilepsy — the defining feature is tendency to recur. In most patients the seizures are generalised (affecting both brain hemispheres) or focal (starting in one region and sometimes spreading).

The causes vary widely. Many cases are genetic or developmental. Others arise from head trauma, stroke, brain tumour, or infection. In many cases the cause remains unknown even after investigation.

Generalised vs focal seizures

The seizure type guides investigation and treatment choice. Some patients have both.

Type A

Generalised seizures

  • Affect both hemispheres from onset (or within seconds).
  • Loss of consciousness is typical.
  • Tonic-clonic (stiffening and shaking), absence (blank stares), or atonic (sudden falls) patterns.
  • EEG abnormality is bilateral and diffuse.

Type B

Focal seizures

  • Start in one brain region, may or may not spread.
  • Awareness can be preserved (focal aware) or lost (focal impaired awareness).
  • Hand movements, lip smacking, or automatisms are common.
  • EEG abnormality is localised.

What we see in clinic

1%

Of the population has active epilepsy at any given time

70%

Of new-onset seizures respond to a single anti-seizure drug

30%

Are drug-resistant and may benefit from surgery

Key facts

01 The EEG is the main investigation — it shows abnormal discharges during or between seizures.
02 MRI is essential to look for structural causes (scar, tumour, malformation).
03 Video-telemetry — recording the patient during a seizure — is the gold standard for locating the seizure focus before surgery.
04 Driving restrictions apply in most countries; seizure freedom (usually 6–12 months) must be confirmed before licensing resumes.
05 Sudden Unexpected Nocturnal Death in Epilepsy (SUDEP) is rare but serious — risk falls with seizure control.

How it is treated

Anti-seizure medication is first-line. Surgery is the next step for drug-resistant epilepsy.

Anti-seizure medication

First-line for all new-onset seizures

  • Monotherapy (one drug) tried first — leveteracetam, sodium valproate, lamotrigine, or lacosamide depending on seizure type
  • If monotherapy fails, a second drug is added (polytherapy)
  • Frequent blood tests and EEGs to assess control and side effects

Ketogenic diet

Adjunctive for focal or generalised seizures

  • High-fat, low-carbohydrate diet used for decades in paediatric epilepsy
  • Works for adults too — about 30% achieve significant seizure reduction
  • Requires dietitian supervision and monitoring

Surgery

Drug-resistant epilepsy (failure of two or more AEDs)

  • Resection: removal of the seizure-generating zone if focal and surgically accessible
  • Disconnection: callosotomy or functional hemispherectomy to prevent spread
  • Neuromodulation: vagus nerve stimulation or responsive neurostimulation (RNS) for multifocal or diffuse seizure zones

Counselling

Ongoing support throughout treatment

  • Psychoeducation about seizure triggers and lifestyle
  • Driving and work implications
  • Pregnancy planning (some AEDs carry teratogenic risk)

Seizure freedom is the goal, but some patients settle for a significant reduction if complete freedom is not achievable.

Related reading

Book a consultation

The secretary schedules first appointments during clinic hours; please have prior imaging, operative notes and a current medication list available at the time of the call.

This page provides general information about epilepsy and is not a substitute for individual medical assessment. If your symptoms are severe or worsening, contact a clinician promptly.